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How many days can you take Tylenol in a row? Extra strength Tylenol should not be taken for more than 10 days unless directed by a doctor. Take no more than 8 extra strength Tylenol per day. The maximum allowable daily dose of Tylenol (acetaminophen) is 4 grams (or 4,000 mg) in adults and 90 mg per kilogram of body weight in children.